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Metabolic Control Analyis 101: Part 1
Tweet What is Metabolic Control Analysis? Broadly speaking, Metabolic Control Analysis is a mathematical approach that allows us to understand and quantify how perturbations to a biochemical pathway...
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Biochemical Control Analyis 101: Part 2
Tweet What is a control coefficient? First we should indicate what we mean by control. The term control has a special meaning in biochemical control analysis. Control refers to the ability of a system...
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Jim Burns’ Ph.D Thesis
Tweet Why on earth should anyone would want to download a Ph.D thesis that is now almost 40 years old and presumably way out of date and completely irrelevant in today’s terabyte data world? Well for...
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Ludicrous as it may sound
Tweet I was reminded the other day of an interesting quote from a 2000 FEBS paper which starts with: “How highly would one rate an economic analysis of a factory that ignored the consumer demand for...
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Misconceptions in Metabolism
Tweet I’m currently at the ISGSB meeting (International Study group for Systems Biology – formally BTK) in Holland. This is a group that values both theoretical analysis and experimentation in...
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Misconceptions in Metabolism II
Tweet A week ago I wrote about some misconceptions in metabolism that arose from a trip to a systems biology workshop in Holland. This week I discovered that Nature is perpetrating similar...
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Michael Savageau’s Book in Print Again
Tweet I’ve been meaning to mention this for some time but Michael Savageau book, ‘Biochemical Systems Analysis’ is available in print again in the form of a paperback from amazon for only $29.95. I...
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Choke points, Load points, Hots spots and Key steps
Tweet Choke points, load points, hot spots, key steps and critical steps are some of the many phrases that have been coined to describe places in a biochemical network where perturbations are said to...
View ArticleBottlenecks and Slow Steps – again
I’ve written a few articles on this blog about the irrationality of bottlenecks and slow steps in metabolism, hoping that one day my fellow scientists will feel the same. Sadly it is not true and...
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Reversibility and Product Inhibition
It is common in biochemistry to categorize reactions as either reversible or irreversible. What do we mean by these terms? Let’s look at a simple reaction such as: where A is transformed to B. The...
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New Textbook on Metabolic Control Analysis
New Textbook Published I am pleased to announce the publication of my new textbook: Introduction to Metabolic Control Analysis “This book is an introduction to control in biochemical pathways. It...
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